Ibiza, Canaries and Mallorca could all join the Government's travel safe lists as it considers "regional" quarantines.
Spain was dramatically added to the UK quarantine list last month sparking a scramble for Brits to get home.
But Transport Secretary Grant Shapps said he may look at regional data instead.
The infection rate in Ibiza, Mallorca and Canaries is much lower than mainland Spain, which caused anger among Brit holidaymakers there.
And Shapps has raised hopes Brits may be able to squeeze in a break without having to self-isolate on return.
He told the BBC: "The islands, particularly the Spanish islands, when Spain went into lockdown, we saw in one the numbers coming up and in the other set the numbers coming down – so we do need to be absolutely sure that you're capturing the disease as it actually is and sometimes it's not quite as straightforward as it sounds."
He added: "However, I think there is a case for regionalisation. I think it's harder to do within a country – people say, with France for example, why don't you just do this region and not the other?
"The answer is it's quite easy to travel about the country so we're not able to do it like that.
"Where there are islands, I think it's something we have said before we will look at and we are looking at. It depends on levels of data you have.
Croatia added to UK watchlist as tourists warned 'only travel if you can quarantine'
"We are looking in to how you can do regionalisation effectively."
This week, Croatia, Austria and Trinidad and Tobago were all added to the UK's quarantine list.
But Portugal has been removed, allowing Brits to travel there without having to quarantine upon return.
The Canary Islands has experienced a rise in daily cases with around 200 reported in the last 24 hours to Friday.
There are a total of 1,400 active cases on the islands at the moment, health officials say.
But Shapps has warned Brits that any air bridges could be axed at short notice.
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